Wholesale N-Acetyl-L-Glutamine Powder Food Grade CAS 2490-97-3
N-Acetyl-L-Glutamine: Product Introduction
N-Acetyl-L-glutamine is an amino acid derivative formed by the conjugation of glutamine with an acetyl group. Structurally, it resembles glutamine; however, the addition of the acetyl group endows it with a critical capability: the efficient penetration of the blood-brain barrier. This ability to traverse the blood-brain barrier gives N-acetyl-L-glutamine a unique advantage in the therapeutic treatment of the nervous system. It acts directly upon brain cells, providing the brain with essential nutrients and protection.
With 12 years of deep-rooted experience in the raw materials industry, YTBIO offers a stable supply chain and a comprehensive product portfolio. Our products feature guaranteed purity, exceptional stability, and excellent water solubility, with all parameters strictly adhering to production standards across various sectors—including food, health products, and dietary supplements. We maintain ample stock to ensure rapid dispatch, thereby fully meeting the diverse procurement and formulation application needs of our global clientele.
Mechanism of Action:
N-acetyl-L-glutamine is capable of crossing the human blood-brain barrier. Upon entering brain tissue, and under the action of specific enzymes, it breaks down into two critically important neuroactive substances: glutamate and gamma-aminobutyric acid (GABA). Together, these two substances modulate the functions of the body's nervous system; they serve to ameliorate impairments in neurological function and can thereby enhance overall brain function.
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Degradation Products |
Mechanism of Action |
Clinical Value |
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Glutamic Acid |
- Participates in central nervous system signal transmission and provides energy for brain tissue- Combines with blood ammonia to form glutamine, reducing blood ammonia levels- Promotes protein/glucose metabolism and repairs cells |
✅ Improves brain function and promotes consciousness recovery |
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γ-Aminobutyric Acid (GABA) |
- Antagonizes the excitotoxicity of glutamic acid to avoid nerve damage- Promotes acetylcholine synthesis and improves brain signal transmission efficiency- Improves energy metabolism in nerve cells and maintains their stress response state- Activates glucose phosphatase to accelerate glucose metabolism for energy supply |
✅ Protects neurons, alleviates brain damage, and relieves anxiety |
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Acetylglutamic Acid |
- Promotes the ornithine cycle to produce urea- Promotes acetylcholine synthesis- Reduces blood ammonia levels and improves brain function |
✅ Reduces blood ammonia levels and improves liver function |
N-Acetyl-L-Glutamine vs. Glutamine
Superior Stability: Resistant to high temperatures, acids, and bases; does not decompose easily, resulting in a longer shelf life.
Excellent Water Solubility: Higher solubility than glutamine, facilitating its incorporation into pharmaceutical formulations and beverages.
High Bioavailability: Acetylation modification enhances absorption efficiency and extends the duration of action.
Health Benefits
Promoting Neuronal Metabolism: N-acetyl-L-glutamine serves as an energy precursor for brain cells, enhancing their utilization of glucose and ameliorating neuronal dysfunction resulting from ischemia and hypoxia. It is widely distributed throughout the body and is capable of crossing the blood-brain barrier, with particularly high concentrations found in the brain, liver, and kidneys. Within renal tubular cells, it undergoes enzymatic hydrolysis by glutaminase—releasing ammonia and converting into acetylglutamic acid. The released ammonia is secreted and excreted via the renal tubules, while the acetylglutamic acid is reabsorbed to participate in the body's metabolic processes.
Regulation of Neurotransmitter Transmission: Upon crossing the blood-brain barrier, N-acetyl-L-glutamine breaks down into glutamate and gamma-aminobutyric acid (GABA). Glutamate participates in information transmission within the central nervous system, while GABA counteracts the excitatory effects of glutamate and improves neuronal metabolism, thereby enhancing brain function.
Combating Oxidative Stress: Mitigating oxidative damage following neuronal injury, reducing inflammatory responses, and creating conditions conducive to repair.
Application Areas Overview
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N-Acetyl-L-Glutamine Application Fields |
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Application Field |
Core Application Scenarios |
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Pharmaceutical Field |
1. Neurological medication: for brain trauma, hepatic coma, memory loss, Alzheimer's disease, etc. |
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Functional Food & Sports Nutrition |
1. Sports recovery supplements: promote muscle repair, relieve training fatigue, improve endurance |
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Cosmetics & Skincare Products |
1. Skin repair and moisturizing: promote stratum corneum repair, soothe sensitivity and redness, improve moisturizing power |
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What key factors should be considered when purchasing N-Acetyl-L-Glutamine powder?
- Purity and Content
- Specifications and Grade
- Physicochemical Parameters
- Certifications and Qualifications
- Source and Manufacturing Process
- Packaging and Storage
- Pricing and Shipping Costs
- Regulatory Compliance
FAQ
Q: What is this product?
A: N-Acetyl-L-Glutamine. It is an advanced derivative of glutamine, characterized by high water solubility and chemical stability, and is easily absorbed and utilized by the human body.
Q: What are its advantages compared to standard glutamine?
A: It exhibits superior resistance to acids, bases, and high temperatures, making it highly resistant to decomposition. It possesses a pure, clean taste with no unpleasant odors, absorbs more rapidly, is capable of crossing the blood-brain barrier, and offers higher bioavailability.
Q: Who is this product suitable for?
A: Fitness enthusiasts and athletes; individuals engaged in intense mental work or those who frequently stay up late; people with sensitive or weak digestive systems; individuals with compromised immunity; and middle-aged to elderly individuals seeking daily nutritional support.
Q: How should it be stored?
A: Store in a sealed container in a cool, dry place away from direct light. Protect from moisture and humidity, and avoid exposure to high temperatures or direct sunlight.
Q: Can this product be taken long-term?
A: Yes, it can be safely taken as a gentle, long-term supplement. It is non-habit-forming; simply continue taking it as needed to maintain benefits.
Q: Do you support OEM/ODM customization projects?
A: Yes, we offer comprehensive, one-stop OEM and ODM customization services. We can tailor solutions to your specific needs, including raw material repackaging, finished powder products, custom formula blending, tablets/capsules, individual packaging, private labeling, and adjustments to product specifications and ratios.
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